Rejuran is an injectable skin treatment built on polynucleotides (PNs) — purified DNA fragments that, in Rejuran’s case, are sourced from salmon and share close structural similarity to human DNA. Rather than simply filling or hydrating the skin, Rejuran works to stimulate the skin’s own repair and regeneration processes at a cellular level.
How it works
Rejuran is composed of highly purified polynucleotides, a more concentrated and refined form of polydeoxyribonucleotides (PDRN) already found naturally in human tissue. Once injected into the skin, these polynucleotides activate fibroblasts to produce new collagen and elastin, improve local blood flow and tissue oxygenation, reduce inflammation, and support DNA repair within skin cells. The result is skin that looks and functions healthier from the inside out, rather than simply appearing temporarily plumped.
What it treats
- Overall skin texture, tone, and elasticity — often described as achieving “glass skin”
- Acne scarring and photodamage
- Under-eye skin quality and fine lines
- The neck and other areas showing early signs of aging
What does the research show?
A 2025 systematic review in the Journal of Cosmetic Dermatology (Lampridou et al.) evaluated polynucleotide-based treatments across a range of aesthetic applications and found consistent improvements in skin quality, elasticity, and hydration, along with a favorable safety profile across the studies reviewed. A 2026 split-face study published in the same journal (Bae et al.) compared injection techniques for polynucleotide treatments, adding to the growing body of clinical evidence supporting this treatment category. As research specific to individual polynucleotide formulations continues to expand, these studies support the broader mechanism and safety profile behind treatments like Rejuran.
What to expect
Rejuran is delivered through a series of small injections, typically administered in a series of sessions spaced several weeks apart for optimal results. It’s common to see mild redness, swelling, or small bumps at the injection sites for a day or two afterward. Results build gradually over the following weeks as new collagen forms, rather than appearing immediately.
Is Rejuran right for you?
Rejuran is well suited for patients who want to improve their skin’s overall quality, texture, and resilience rather than add volume. Good candidates often have acne scarring, photodamage, crepey under-eye skin, or early signs of aging. A consultation at HALO Beverly Hills is the best way to determine whether Rejuran, another treatment, or a combination approach is right for your goals.
Frequently asked questions
Does Rejuran hurt? Most patients tolerate the injections well. A topical numbing cream can be applied beforehand to minimize any discomfort during treatment.
How many sessions will I need? Rejuran is typically administered as a series of treatments spaced several weeks apart, with the exact number depending on your skin concerns and goals. This will be discussed during your consultation.
Is there any downtime? Downtime is minimal. You may notice mild redness, swelling, or small bumps at the injection sites for a day or two, but most patients return to their normal activities right away.